Praful R. Nair

Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images

CODAvision provides a user-friendly interface for rapid, customizable medical image segmentation using deep learning, enabling non-experts to train and evaluate models across diverse imaging modalities.

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

Hyper-migratory CAR T cells alleviate ovarian cancer metastatic burden and improve prognosis

This study shows hyper-migratory CAR T cells reduce ovarian cancer metastasis and improve survival in mice.

3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids

This paper develops a 3D multi-compartment assembloid that mimics human endometrial tissue and its menstrual cycle phases, enabling study of compartment-specific hormonal responses and paracrine signaling.

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.