Profiling and Targeting of Regulatory RNAs to Upregulate Gene Expression
Brynn N. Akerberg, Bryan J. Matthews, Yuting Liu, Cécile Mathieu, Jenna Williams, Salomé Manska, Jiaqi Huang, Yuichi Nishi, Abeer Almutairy, Eric Coughlin, Gabriel Golczer, Scott Waldron, Isabella Pellegrino, Yuchun Guo, Evan Cohick, , David A. Bumcrot
This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.
bioRxiv · Apr 23, 2026 · PreprintGenomics