Alla A. Sigova

This paper demonstrates that antisense oligonucleotides targeting LDLR regulatory RNAs increase LDLR expression and reduce LDL-cholesterol in a mouse model.

This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

JMnorm improves normalization of epigenetic data by jointly normalizing multiple features across cell types and conditions, preserving biological relationships and enhancing downstream analysis.