Brynn N. Akerberg

This paper demonstrates that antisense oligonucleotides targeting LDLR regulatory RNAs increase LDLR expression and reduce LDL-cholesterol in a mouse model.

This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

The paper identifies how CHD4/NuRD is recruited to cardiac gene loci via interactions with GATA4, NKX2-5, and TBX5, revealing its role in repressing non-cardiac gene programs during heart development.

The paper models TBX5 haploinsufficiency in iPSC-derived cardiomyocytes to identify gene regulatory network imbalances linked to congenital heart disease.