Author

David A. Bumcrot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:batch correction / integration· 1

Frequent Co-Authors

Alla A. SigovaiD· 4 shared Brynn N. AkerbergiD· 3 shared Gabriel GolczeriD· 3 shared Jiaqi HuangiD· 3 shared Alfica Sehgal· 2 shared Bryan J. MatthewsiD· 2 shared Daniel F. TardiffiD· 2 shared Jenna Williams· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Alla A. SigovaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antisense Oligonucleotides Targeting an LDLR Regulatory RNA Increase LDLR Expression and Reduce LDL-cholesterol in Vivo

Keerthana Gnanapradeepan, Salomé Manska, Brian Schwartz, Gabriel Golczer, Jiaqi Huang, Rachana S. Kelkar, Andrew M. Masteller, Shama Pilankar, Marianne Richter, Scott Waldron, Brynn N. Akerberg, Dale C. Guenther, Alla A. Sigova, David A. Bumcrot, Daniel F. Tardiff

This paper demonstrates that antisense oligonucleotides targeting LDLR regulatory RNAs increase LDLR expression and reduce LDL-cholesterol in a mouse model.

bioRxiv · Jun 4, 2026 · PreprintMolecular Biology

Profiling and Targeting of Regulatory RNAs to Upregulate Gene Expression

Brynn N. Akerberg, Bryan J. Matthews, Yuting Liu, Cécile Mathieu, Jenna Williams, Salomé Manska, Jiaqi Huang, Yuichi Nishi, Abeer Almutairy, Eric Coughlin, Gabriel Golczer, Scott Waldron, Isabella Pellegrino, Yuchun Guo, Evan Cohick, , David A. Bumcrot

This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.

bioRxiv · Apr 23, 2026 · PreprintGenomics

Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration

Gokul Ramaswami, Yeliz Yuva-Aydemir, Brynn N. Akerberg, Bryan J. Matthews, Jenna Williams, Gabriel Golczer, Jiaqi Huang, Ali Al Abdullatif, Dann Huh, Linda C. Burkly, Sandra J. Engle, Iris Grossman, Alfica Sehgal, Alla A. Sigova, Robert T. Fremeau, , David A. Bumcrot

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

Scientific Reports · Jan 25, 2024Peer-reviewedGenomics

JMnorm: a novel Joint Multi-feature normalization method for integrative and comparative epigenomics

Guanjue Xiang, Yuchun Guo, David A. Bumcrot, Alla A. Sigova

JMnorm improves normalization of epigenetic data by jointly normalizing multiple features across cell types and conditions, preserving biological relationships and enhancing downstream analysis.

Nucleic Acids Research · Nov 15, 2023Peer-reviewedSystems Biology