Antisense Oligonucleotides Targeting an LDLR Regulatory RNA Increase LDLR Expression and Reduce LDL-cholesterol in Vivo
Keerthana Gnanapradeepan, Salomé Manska, Brian Schwartz, Gabriel Golczer, Jiaqi Huang, Rachana S. Kelkar, Andrew M. Masteller, Shama Pilankar, Marianne Richter, Scott Waldron, Brynn N. Akerberg, Dale C. Guenther, Alla A. Sigova, David A. Bumcrot, Daniel F. Tardiff
This paper demonstrates that antisense oligonucleotides targeting LDLR regulatory RNAs increase LDLR expression and reduce LDL-cholesterol in a mouse model.
bioRxiv · Jun 4, 2026 · PreprintMolecular Biology