Author

C. A. Engelhart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

D. Schnappinger· 2 shared B. Bosch· 1 shared B. Yan· 1 shared D. Sullivan· 1 shared H. Wang· 1 shared J. M. Rock· 1 shared J. S. Chang· 1 shared K. Eckartt· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

D. Schnappinger

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis

S. Li, N. C. Poulton, J. S. Chang, Z. A. Azadian, M. A. Dejusus, N. Ruecker, M. D. Zimmerman, K. Eckartt, B. Bosch, C. A. Engelhart, D. Sullivan, M. Gengenbacher, V. A. Dartois, D. Schnappinger, J. M. Rock

This study uses a CRISPR interference platform to map drug resistance pathways in Mtb, identifying new intrinsic and acquired resistance mechanisms and potential drug targets.

bioRxiv · Nov 27, 2021 · PreprintMicrobiology

Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

H. Wang, M. Xu, C. A. Engelhart, X. Zhang, B. Yan, M. Pan, Y. Xu, S. Fan, R. Liu, L. Xu, L. Hua, D. Schnappinger, S. Chen

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

bioRxiv · Oct 27, 2020Biochemistry