Author

J. M. Rock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. C. Poulton· 4 shared S. Li· 4 shared D. Schnappinger· 3 shared M. A. DeJesus· 3 shared Z. A. Azadian· 3 shared B. Bosch· 2 shared S. Ehrt· 2 shared A. I. Wong· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

N. C. Poulton

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6 papers

Recent·Most cited

Beyond antibiotic resistance: the whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

N. C. Poulton, M. A. DeJesus, V. Munsamy-Govender, C. G. Roberts, Z. A. Azadian, B. Bosch, K. M. Lin, S. Li, J. M. Rock

This study identifies signals that activate the whiB7 stress response in mycobacteria, revealing its role in coordinating an adaptive response to alanine starvation.

bioRxiv · Jun 2, 2023 · PreprintMicrobiology

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

X. Ju, S. Li, R. Froom, L. Wang, M. Lilic, E. A. Campbell, J. M. Rock, S. Liu

This study profiles the Mtb transcriptome using SEnd-seq and finds that incomplete transcripts dominate due to low transcription processivity and transcription-translation coupling.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

A. I. Wong, T. Beites, K. A. Planck, S. Li, N. C. Poulton, K. Rhee, D. Schnappinger, S. Ehrt, J. M. Rock

This study identifies cAMP as a key mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis by analyzing the role of the essential adenylate cyclase Rv3645.

bioRxiv · Jul 7, 2022Microbiology

Mutations in rv0678 confer low-level resistance to benzothiazinone DprE1 inhibitors in M. tuberculosis

N. C. Poulton, Z. A. Azadian, M. A. DeJesus, J. M. Rock

This study identifies rv0678 mutations as a mechanism of resistance to benzothiazinone DprE1 inhibitors in M. tuberculosis, showing cross-resistance to BTZ043 and PBTZ169.

bioRxiv · Jun 29, 2022 · PreprintMicrobiology

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis

S. Li, N. C. Poulton, J. S. Chang, Z. A. Azadian, M. A. Dejusus, N. Ruecker, M. D. Zimmerman, K. Eckartt, B. Bosch, C. A. Engelhart, D. Sullivan, M. Gengenbacher, V. A. Dartois, D. Schnappinger, J. M. Rock

This study uses a CRISPR interference platform to map drug resistance pathways in Mtb, identifying new intrinsic and acquired resistance mechanisms and potential drug targets.

bioRxiv · Nov 27, 2021 · PreprintMicrobiology

The Mycobacterium tuberculosis transposon sequencing database (MtbTnDB): a large-scale guide to genetic conditional essentiality

A. Jinich, A. Zaveri, M. A. DeJesus, E. Flores-Bautista, R. Almada-Monter, C. M. Smith, C. M. Sassetti, J. M. Rock, S. Ehrt, D. Schnappinger, T. R. Ioerger, K. Y. Rhee

The paper builds MtbTnDB, a database of Mtb TnSeq screens, enabling comparison of genetic essentiality across conditions and analysis of gene function.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology