Author

Z. A. Azadian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:multiple species· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

J. M. Rock· 3 shared N. C. Poulton· 3 shared B. Bosch· 2 shared M. A. DeJesus· 2 shared S. Li· 2 shared C. A. Engelhart· 1 shared C. G. Roberts· 1 shared D. Schnappinger· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

J. M. Rock

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 2, 2023

Beyond antibiotic resistance: the whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

N. C. Poulton, M. A. DeJesus, V. Munsamy-Govender…·J. M. Rock

This study identifies signals that activate the whiB7 stress response in mycobacteria, revealing its role in coordinating an adaptive response to alanine starvation.

DOI 10.1101/2023.06.02.543512

multiple speciesgenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivPreprintJun 29, 2022

Mutations in rv0678 confer low-level resistance to benzothiazinone DprE1 inhibitors in M. tuberculosis

N. C. Poulton, Z. A. Azadian, M. A. DeJesus, J. M. Rock

This study identifies rv0678 mutations as a mechanism of resistance to benzothiazinone DprE1 inhibitors in M. tuberculosis, showing cross-resistance to BTZ043 and PBTZ169.

DOI 10.1101/2022.06.29.498178

humangenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivPreprintNov 27, 2021

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis

S. Li, N. C. Poulton, J. S. Chang…·J. M. Rock

This study uses a CRISPR interference platform to map drug resistance pathways in Mtb, identifying new intrinsic and acquired resistance mechanisms and potential drug targets.

DOI 10.1101/2021.11.27.469863

humanwhole-genome sequencing

𝕏 PostBluesky