Author

C. A. Ramirez-Sarmiento

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Approach:mechanistic / dynamical model· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1

Frequent Co-Authors

I. Artsimovitch· 2 shared P. Galaz-Davison· 2 shared S. H. Knauer· 2 shared B. Loll· 1 shared B. Wang· 1 shared E. A. Komives· 1 shared E. A. Roman· 1 shared G. A. Belogurov· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

I. Artsimovitch

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3 papers

Recent·Most cited

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

P. K. Zuber, N. Said, T. Hilal, B. Wang, B. Loll, J. Gonzlez-Higueras, C. A. Ramirez-Sarmiento, G. A. Belogurov, I. Artsimovitch, M. Wahl, S. H. Knauer

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

bioRxiv · Jun 26, 2023Biochemistry

The N-terminal domain of RfaH plays an active role in protein fold-switching

P. Galaz-Davison, E. A. Roman, C. A. Ramirez-Sarmiento

This paper uses molecular dynamics to show that the N-terminal domain of RfaH influences its C-terminal fold-switching by stabilizing the β-barrel structure during interdomain dissociation.

bioRxiv · Mar 18, 2021Biophysics

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

P. Galaz-Davison, J. A. Molina, S. Silletti, E. A. Komives, S. H. Knauer, I. Artsimovitch, C. A. Ramirez-Sarmiento

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

Biophysical Journal · Jan 1, 2020Peer-reviewedBiophysics