Author

T. Hilal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Wang· 3 shared I. Artsimovitch· 3 shared M. C. Wahl· 3 shared N. Said· 3 shared B. Loll· 2 shared M. Finazzo· 2 shared A. Beck-Sickinger· 1 shared A. Koch· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

B. Wang

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Author profile →

6 papers

Recent·Most cited

Sm-like protein Rof inhibits transcription termination factor Rho by binding site obstruction and conformational insulation

N. Said, M. Finazzo, T. Hilal, B. Wang, T. L. Selinger, D. Gjorgjevikj, I. Artsimovitch, M. C. Wahl

This study identifies Rof as an inhibitor of the transcription termination factor Rho, showing it blocks Rho's activity through structural obstruction and conformational changes.

bioRxiv · Aug 30, 2023Biochemistry

Transcription termination factor {rho} polymerizes under stress

B. Wang, N. Said, T. Hilal, M. Finazzo, M. C. Wahl, I. Artsimovitch

This study shows that Escherichia coli {rho} forms higher-order oligomers under stress, linking transcription termination to cellular physiology.

bioRxiv · Aug 18, 2023Microbiology

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

P. K. Zuber, N. Said, T. Hilal, B. Wang, B. Loll, J. Gonzlez-Higueras, C. A. Ramirez-Sarmiento, G. A. Belogurov, I. Artsimovitch, M. Wahl, S. H. Knauer

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

bioRxiv · Jun 26, 2023Biochemistry

ADAPs intrinsically disordered region is an actin sponge regulating T cell motility

N. Dadwal, J. Degen, J. Sticht, T. Hilal, T. Wegner, P. Reichardt, R. Lyck, M. Hons, M. Abadier, C. Mix, B. Kuropka, H. Stephanowitz, F. Liu, B. Schraven, C. Wuelfing, , C. Freund

This study identifies ADAP's intrinsically disordered region as an actin sponge that regulates T cell motility by promoting actin polymerization and bundling.

bioRxiv · Dec 14, 2021 · PreprintBiochemistry

Rapid high-resolution structure analysis of small, biotechnologically relevant enzymes by cryo-electron microscopy

N. Dimos, C. P. O. Helmer, A. M. Chanique, M. C. Wahl, R. Kourist, T. Hilal, B. Loll

This study demonstrates that cryo-EM can achieve high-resolution structures of small plant enzymes, enabling faster development of biocatalysts for terpenes and terpenoids.

bioRxiv · Jun 15, 2021 · PreprintBiophysics

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry