Author

S. H. Knauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

I. Artsimovitch· 3 shared P. K. Zuber· 3 shared C. A. Ramirez-Sarmiento· 2 shared K. Schweimer· 2 shared B. Loll· 1 shared B. Wang· 1 shared E. A. Komives· 1 shared G. A. Belogurov· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

I. Artsimovitch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

P. K. Zuber, N. Said, T. Hilal, B. Wang, B. Loll, J. Gonzlez-Higueras, C. A. Ramirez-Sarmiento, G. A. Belogurov, I. Artsimovitch, M. Wahl, S. H. Knauer

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

bioRxiv · Jun 26, 2023Biochemistry

Structural and thermodynamic analyses of the β-to-α transformation in RfaH reveal principles of fold-switching proteins

P. K. Zuber, T. Daviter, R. Heissmann, U. Persau, K. Schweimer, S. H. Knauer

This study analyzes the structural and thermodynamic properties of RfaH and NusG/Spt5-KOW domains to understand the mechanisms of fold-switching in proteins.

bioRxiv · Jan 14, 2022Biophysics

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

P. Galaz-Davison, J. A. Molina, S. Silletti, E. A. Komives, S. H. Knauer, I. Artsimovitch, C. A. Ramirez-Sarmiento

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

Biophysical Journal · Jan 1, 2020Peer-reviewedBiophysics

The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

P. K. Zuber, I. Artsimovitch, M. NandyMazumdar, Z. Liu, Y. Nedialkov, K. Schweimer, P. Roesch, S. H. Knauer

The paper shows RfaH, a transcription factor, binds to a hairpin structure in the non-template DNA strand via a conserved pause sequence, revealing a new mechanism for transcriptional regulation.

bioRxiv · Apr 26, 2018Biochemistry