I. Artsimovitch

Force and the α-C-terminal domains bias RNApolymerase recycling

The paper investigates how force and α-C-terminal domains influence RNA polymerase recycling after termination, showing force biases diffusion direction and promoter recognition.

Sm-like protein Rof inhibits transcription termination factor Rho by binding site obstruction and conformational insulation

This study identifies Rof as an inhibitor of the transcription termination factor Rho, showing it blocks Rho's activity through structural obstruction and conformational changes.

Transcription termination factor {rho} polymerizes under stress

This study shows that Escherichia coli {rho} forms higher-order oligomers under stress, linking transcription termination to cellular physiology.

Concerted transformation of a hyper-paused transcription complex and its reinforcing protein

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

Reciprocating RNA Polymerase batters throughroadblocks

This study investigates how RNA polymerase navigates protein roadblocks in E. coli, showing force-dependent effects and the role of GreA in facilitating passage.

NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain

This study investigates NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain, showing that Nsp12 NMPylates native Nsp9 and that NiRAN residues are essential for this process.

Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops

The paper shows that positive supercoiling helps RNA polymerase bypass LacI-mediated DNA loops in E. coli by reducing pauses and enhancing dissociation of roadblocks.

Accounting for RNA polymerase heterogeneity reveals state switching and two distinct long-lived backtrack states escaping through cleavage

The paper uses high-throughput magnetic tweezers to study E. coli RNA polymerase dynamics, identifying two long-lived backtrack pause states and showing RNA cleavage governs recovery from deep backtracks.

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing

The paper investigates how ligand binding affects the interaction between riboswitch folding and transcriptional pausing in bacterial RNA polymerase.

Structural basis for transcript elongation control by NusG/RfaH universal regulators

This study determines the structural basis of how NusG and RfaH regulate transcript elongation by suppressing backtracking and pausing in bacterial RNA polymerase complexes.

The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

The paper shows RfaH, a transcription factor, binds to a hairpin structure in the non-template DNA strand via a conserved pause sequence, revealing a new mechanism for transcriptional regulation.