Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes
B. Shao, M. Killion, A. Oliver, C. Vang, F. Zeleke, K. Neikirk, Z. Vue, E. Garza-Lopez, J.-q. Shao, M. Mungai, J. Lam, Q. Williams, C. Altamura, A. Whiteside, K. Kabugi, , A. Hinton
This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.
bioRxiv · May 20, 2023Physiology