C. Aumeier

Running Kinesin-1 shapes the microtubule acetylation gradient

The paper shows that kinesin-1-induced damage sites regulate microtubule acetylation by enabling HDAC6 entry, while TAT1 acetylation is independent of kinesin-1, leading to an exponential acetylation gradient in cells.

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.

The effect of motor-induced shaft dynamics on microtubule stability and length

This study investigates how molecular motors affect microtubule stability and length through tubulin exchange along the shaft, revealing novel insights into microtubule network regulation.

Phase separation of +TIP-networks regulates microtubule dynamics

This study shows that CLIP-170 and EB3 undergo phase separation to form liquid networks that regulate microtubule dynamics by enhancing growth speed and reducing depolymerization.

Motor usage imprints microtubule stability in the shaft

The paper shows that molecular motor activity on microtubules increases their average length and densifies the network, influencing cell polarity through dimer exchange along the shaft.

Kinesin-1 motility traced by an activity-based precipitating dye

This study develops a fluorogenic substrate that visualizes kinesin-1 motility in live cells by producing a precipitating dye along its transport path.

Self-repair protects microtubules from their destruction by molecular motors

The paper investigates how molecular motors affect microtubule stability and discovers a self-repair mechanism that counteracts motor-induced damage.

Lattice defects induce microtubule self-renewal

This study shows that microtubules can exchange dimers along their shaft, requiring lattice defects, enabling self-renewal and potential regulation of signaling and structural changes.