Liquid-liquid phase separation of the chromosomal passenger complex drives parallel bundling of midzone microtubules
E. Niedzialkowska, T. M. Truong, L. A. Eldredge, S. Redemann, D. Chretien, T. Stukenberg
This study shows the Chromosomal Passenger Complex (CPC) undergoes liquid-liquid phase separation to generate parallel microtubule bundles in vitro and in cells, revealing a kinase-independent role in spindle midzone formation.
bioRxiv · Jan 7, 2022 · PreprintCell Biology