B. Fierz

Chemically di-ubiquitylated H1 variants reveal position-dependent stimulation of the DNA repair protein RNF168

This study creates di-ubiquitylated H1 variants to show position-dependent stimulation of RNF168, a DNA repair protein, and demonstrates how these variants guide RNF168 recruitment to DNA breaks.

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

This study shows CENP-A and CENP-B collaborate to create an open centromeric chromatin state through dynamic interactions and structural changes.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1

This study shows that Torsin ATPases regulate LAP1's chromatin interaction, affecting mitotic chromosome segregation and nuclear morphology.

Disordered Proteins Enable Histone Chaperoning on the Nucleosome

The paper shows that disordered regions in proteins like H1 enable competitive displacement by histone chaperones such as prothymosin on the nucleosome.

The mechanistic basis for chromatin invasion and remodeling by the yeast pioneer transcription factor Rap1

This study reveals how the yeast pioneer transcription factor Rap1 invades and remodels chromatin by opening fiber structure and collaborating with RSC to destabilize promoter nucleosomes.

KAP1 is an antiparallel dimer with a natively functional asymmetry

This paper shows KAP1 forms an antiparallel dimer with a native asymmetry, which affects its SUMOylation and interaction with HP1.