The paper identifies and characterizes a new human polyomavirus, HPyV16, from skin and fecal samples, showing divergence from HPyV6 and suggesting human tropism.

bioRxiv · Jun 22, 2023Microbiology

A Multivalent Polyomavirus Vaccine Elicits Durable Neutralizing Antibody Responses in Macaques

A. Peretti, D. G. Scorpio, W.-P. Kong, Y.-Y. S. Pang, M. P. McCarthy, K. Ren, M. Jackson, B. S. Graham, C. B. Buck, P. M. McTamney, D. V. Pastrana

This study shows a multivalent polyomavirus vaccine induces high, durable neutralizing antibodies in macaques without adverse effects.

bioRxiv · Sep 26, 2022Immunology

A novel lineage of polyomaviruses identified in bark scorpions

K. Schmidlin, S. Kraberger, C. Cook, D. F. DeNardo, R. S. Fontenele, K. Van Doorslaer, D. P. Martin, C. B. Buck, A. Varsani

The paper identifies eight novel polyomaviruses in bark scorpions and shows evidence of host-virus co-evolution with arthropods and chordates.

bioRxiv · May 12, 2021Microbiology

A New Comprehensive Catalog of the Human Virome Reveals Hidden Associations with Chronic Diseases

M. J. Tisza, C. B. Buck

The paper introduces Cenote-Taker 2, a tool that identifies over 50,000 unique human viruses and finds 1,700 virus-disease associations using metagenomic data.

bioRxiv · Nov 1, 2020Microbiology

Cenote-Taker 2 Democratizes Virus Discovery and Sequence Annotation

M. J. Tisza, A. K. Belford, G. Dominguez Huerta, B. Bolduc, M. B. Sullivan, C. B. Buck

Cenote-Taker 2 identifies and annotates viral sequences from contigs, improving virome discovery and database curation.

bioRxiv · Sep 15, 2020Microbiology

Identification of Adomavirus Virion Proteins

N. L. Welch, M. J. Tisza, G. J. Starrett, A. K. Belford, D. V. Pastrana, Y.-Y. S. Pang, J. T. Schiller, P. An, P. G. Cantalupo, J. M. Pipas, S. Koda, K. Subramaniam, T. B. Waltzek, C. Bian, Q. Shi, , C. B. Buck

This paper identifies virion proteins of adomaviruses, linking them to adenoviruses and adintoviruses, and suggests a shared evolutionary history among small DNA tumor viruses.

bioRxiv · Mar 4, 2020 · PreprintMicrobiology

Adintoviruses: An Animal-Tropic Family of Midsize Eukaryotic Linear dsDNA (MELD) Viruses

G. J. Starrett, M. J. Tisza, N. L. Welch, A. Belford, A. Peretti, D. V. Pastrana, C. B. Buck

The paper identifies a new family of animal-specific viruses, Adintoviridae, related to adenoviruses and retroviral integrases, found in animal genomes and metagenomes.

bioRxiv · Feb 27, 2020 · PreprintMicrobiology

Discovery of several thousand highly diverse circular DNA viruses

M. J. Tisza, D. V. Pastrana, N. L. Welch, B. Stewart, A. Peretti, G. J. Starrett, Y.-Y. S. Pang, S. R. Krishnamurthy, P. A. Pesavento, D. H. McDermott, P. M. Murphy, J. L. Whited, B. Miller, J. M. Brenchley, S. P. Rosshart, , C. B. Buck

The paper identifies and characterizes thousands of new circular DNA viruses from animal samples using a bioinformatics pipeline and artificial neural networks.

bioRxiv · Sep 17, 2019Microbiology

Infectious Entry of Merkel Cell Polyomavirus

M. Becker, M. Dominguez, L. Greune, L. Soria-Martinez, M. Pfleiderer, R. M. Schowalter, C. B. Buck, B. S. Blaum, M. A. SCHMIDT, M. Schelhaas

This study investigates the infectious entry mechanism of MCPyV, revealing caveolar/lipid raft-mediated endocytosis and endosomal membrane envelope acquisition, with endosome-to-ER trafficking as a bottleneck.

bioRxiv · Oct 30, 2018Microbiology