C. B. Coyne

Human trophoblast stem cells can be used to model placental susceptibility to Toxoplasma gondii and highlight the critical importance of the trophoblast cell surface in pathogen resistance

This study uses human trophoblast stem cells to model placental resistance to Toxoplasma gondii and Listeria monocytogenes, showing that syncytiotrophoblasts are more resistant than cytotrophoblasts.

An in vivo model of echovirus-induced meningitis in neonates

This paper develops an in vivo neonatal mouse model of echovirus-induced meningitis and identifies key factors required for viral replication and disease progression.

Enterovirus replication and dissemination are differentially controlled by type I and III interferons in the GI tract

This study investigates the differential roles of type I and III interferons in enterovirus replication and dissemination in the gastrointestinal tract using a neonatal mouse model.

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

The paper develops trophoblast and decidua organoids to study antiviral defenses at the maternal-fetal interface, showing differential innate immune responses and susceptibility to HCMV.

Toxoplasma gondii GRA28 is required for placenta-specific induction of the regulatory chemokine CCL22 in human and mouse.

This paper identifies T. gondii GRA28 as the effector required for placenta-specific induction of CCL22 in human and mouse, linking it to parasite dissemination and immune modulation.

BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection

The paper identifies ARFGAP1 and TMED9 as host factors that interact with BPIFB3 to regulate non-canonical autophagy and enhance enterovirus and flavivirus replication.

Type III interferon signaling restricts Enterovirus 71 infection of goblet cells

This study shows EV71 infects goblet cells in the human intestinal epithelium and that type III IFNs restrict its replication.

Rift Valley fever virus induces fetal demise through direct placental infection

This study shows RVFV causes fetal demise by directly infecting the placenta in pregnant rats and humans, revealing vertical transmission in non-livestock species.

Human placental syncytiotrophoblasts restrict Toxoplasma gondii vertical transmission at two distinct stages and induce CCL22 in response to infection