J. P. Boyle

Human trophoblast stem cells can be used to model placental susceptibility to Toxoplasma gondii and highlight the critical importance of the trophoblast cell surface in pathogen resistance

This study uses human trophoblast stem cells to model placental resistance to Toxoplasma gondii and Listeria monocytogenes, showing that syncytiotrophoblasts are more resistant than cytotrophoblasts.

ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii reveals novel virulence factors implicated in host cell invasion

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

Evolutionary loss of inflammasomes in carnivores to facilitate carriage of zoonotic infections

The paper investigates evolutionary changes in inflammasome pathways in carnivores, finding reduced immune sensing that may facilitate zoonotic pathogen carriage.

Toxoplasma gondii GRA28 is required for placenta-specific induction of the regulatory chemokine CCL22 in human and mouse.

This paper identifies T. gondii GRA28 as the effector required for placenta-specific induction of CCL22 in human and mouse, linking it to parasite dissemination and immune modulation.

Parasite manipulation of the host cell cycle as a means to block inflammatory signaling and promote intracellular replication

This study compares the host response and cell cycle effects of two parasites, finding that H. hammondi induces stronger host responses and cell cycle arrest than T. gondii, which suppresses the host's SASP response to enhance its own replication.

Human placental syncytiotrophoblasts restrict Toxoplasma gondii vertical transmission at two distinct stages and induce CCL22 in response to infection

Hammondia hammondi has a developmental program in vitro that mirrors its stringent two host life cycle

This study compares the in vitro developmental programs of Hammondia hammondi and Toxoplasma gondii, revealing distinct growth states and life cycle characteristics in H. hammondi.