A. Martinez-Sanchez

Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells

This study shows that LKB1 deletion in mouse pancreatic beta cells causes widespread chromatin accessibility changes and affects gene expression, including neuronal genes.

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

This study shows 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility in adipose precursor cells, impacting gene expression and fat mass.

Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein

This study observes SARS-CoV-2 Spike protein-induced platelet deformation and activation using cryo-ET and live imaging, identifying integrin vβ3 as a binding target.

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

Cryo-electron tomography suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules

The paper uses cryo-ET to identify lumenal particles in neuronal microtubules, suggesting some are tubulin chaperones involved in maintaining microtubule structure during neuronal differentiation.

Structural plasticity of Atg18 oligomers: organization of assembled tubes and scaffolds at the isolation membrane

This study determines the cryo-EM structures of Atg18 oligomers and their interactions with lipid membranes, revealing their role in coordinating autophagy machinery components.

In situ architecture of neuronal alpha-Synuclein inclusions

This study uses cryo-ET to show that neuronal alpha-Synuclein inclusions contain fibrils intermixed with cellular membranes and are nucleated by oligomers.

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell identity and function.

This study investigates the role of Pax6os1/PAX6-AS1 in beta cell identity and function, finding that its upregulation in diabetes contributes to impaired functionality and that targeting it may improve glucose homeostasis.

Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

This study shows that reducing TCF7L2 in adipocytes impairs glucose tolerance in male mice through decreased insulin secretion, incretins, and lipid metabolism dysregulation, with effects dependent on gender, age, and diet.

High throughput identification of miR-145 targets in human articular chondrocytes

This study identifies miR-145 targets in human articular chondrocytes using RIP-seq and validation methods, showing it regulates genes involved in cartilage homeostasis and inflammation.

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

Template-free detection and classification of heterogeneous membrane-bound complexes in cryo-electron tomograms

The paper develops a template-free method to detect and classify membrane-bound complexes in cryo-ET data, revealing previously undetected ER translocon species and their structural and spatial characteristics.

Tricalbin-mediated contact sites control ER curvature to maintain plasma membrane integrity

The paper identifies Tcb proteins as mediators of ER curvature at ER-PM contact sites, facilitating lipid transport to maintain plasma membrane integrity under stress.