Author

C. C. Posthuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 1

Frequent Co-Authors

E. J. Snijder· 3 shared J. Zevenhoven-Dobbe· 2 shared A. H. De Wilde· 1 shared A. W. M. de Jong· 1 shared D. Jarhad· 1 shared H. W. Lee· 1 shared L. Boomaars-van der Zanden· 1 shared L. S. Jeong· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. J. Snijder

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

6',6'-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication

N. S. S. Ogando, J. Zevenhoven-Dobbe, D. Jarhad, S. K. Tripathi, H. W. Lee, L. S. Jeong, E. J. Snijder, C. C. Posthuma

This paper shows that 6',6'-difluoro-aristeromycin inhibits MERS-CoV replication but is cytotoxic and needs improvement for broader antiviral use.

bioRxiv · May 20, 2021 · PreprintMicrobiology

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of Middle East respiratory syndrome-coronavirus

N. S. Ogando, J. Zevenhoven-Dobbe, C. C. Posthuma, E. J. Snijder

This study shows that the ExoN activity of MERS-CoV nsp14 is essential for viral RNA synthesis, unlike in MHV and SARS-CoV where it primarily enhances replication fidelity.

Journal of Virology · Nov 9, 2020Peer-reviewedMicrobiology

Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits

A. H. De Wilde, L. Boomaars-van der Zanden, A. W. M. de Jong, M. Barcena, E. J. Snijder, C. C. Posthuma

This study identifies adaptive mutations in nsp2 and nsp5 of equine arteritis virus that confer resistance to cyclophilin inhibitors, revealing their role in the mechanism of action of these antiviral compounds.

bioRxiv · Mar 24, 2019Microbiology