Author

A. H. de Wilde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:protein structure· 1 Organism:rat· 1

Frequent Co-Authors

E. J. Snijder· 4 shared A. W. M. de Jong· 2 shared D. H. Barouch· 2 shared F. Wegmann· 2 shared H. Schuitemaker· 2 shared J. Custers· 2 shared J. E. M. van der Lubbe· 2 shared M. Barcena· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersImmunology

E. J. Snijder

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Author profile →

4 papers

Recent·Most cited

Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques

L. Solforosi, H. Kuipers, S. K. Rosendahl Huber, J. E. M. van der Lubbe, L. Dekking, D. N. Czapska-Casey, A. Izquierdo Gil, M. Baert, J. Drijver, J. Vaneman, E. van Huizen, Y. Choi, J. Vreugdenhil, S. Kroos, A. H. de Wilde, , R. C. Zahn

This study evaluates one- and two-dose regimens of the Ad26.COV2.S vaccine in rhesus macaques, showing higher antibody responses with two doses and protection against SARS-CoV-2 in aged animals.

bioRxiv · Nov 17, 2020Immunology

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R. Bos, L. Rutten, J. E. M. van der Lubbe, M. J. G. Bakkers, G. Hardenberg, F. Wegmann, D. Zuijdgeest, A. H. de Wilde, A. Koornneef, A. Verwilligen, D. van Manen, T. Kwaks, R. Vogels, T. J. Dalebout, S. K. Myeni, , H. Schuitemaker

This paper evaluates a prefusion-stabilized SARS-CoV-2 Spike protein vaccine candidate, Ad26.COV2.S, showing potent neutralizing and Th1-polarized immune responses in mice.

bioRxiv · Jul 30, 2020Immunology

A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis

E. J. Snijder, R. W. A. L. Limpens, A. H. de Wilde, A. W. M. de Jong, J. C. Zevenhoven-Dobbe, H. J. Maier, F. G. A. Faas, A. J. Koster, M. Barcena

This study identifies double-membrane vesicles (DMVs) as the central site for viral RNA synthesis in coronaviruses, providing a unifying model of the replication organelle.

bioRxiv · Mar 24, 2020Microbiology

Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits

A. H. De Wilde, L. Boomaars-van der Zanden, A. W. M. de Jong, M. Barcena, E. J. Snijder, C. C. Posthuma

This study identifies adaptive mutations in nsp2 and nsp5 of equine arteritis virus that confer resistance to cyclophilin inhibitors, revealing their role in the mechanism of action of these antiviral compounds.

bioRxiv · Mar 24, 2019Microbiology