Author

C. Caillet-Saguy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

N. Wolff· 5 shared A. Haouz· 2 shared A. Mechaly· 2 shared B. Boeda· 2 shared B. Neitthoffer· 2 shared F. Alvarez· 2 shared G. Gogl· 2 shared R. Vincentelli· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersBiochemistry

N. Wolff

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Author profile →

6 papers

Recent·Most cited

A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ Binding Motif to the cytoplasm.

B. Neitthoffer, F. Alvarez, F. Larrous, C. Caillet-Saguy, S. Etienne-Manneville, B. Boeda

The paper identifies a short sequence in the SARS-CoV-2 envelope protein tail that regulates the accessibility of its PDZ-binding motif to the cytoplasm.

bioRxiv · Aug 29, 2023Cell Biology

Interactions of the Protein Tyrosine Phosphatase PTPN3 with Viral and Cellular Partners through its PDZ Domain: Insights into Structural Determinants and Phosphatase Activity

M. Genera, B. Colcombet-Cazenave, A. Croitoru, B. Raynal, A. Mechaly, J. Caillet, A. Haouz, N. Wolff, C. Caillet-Saguy

This study investigates the interactions of PTPN3's PDZ domain with viral and cellular PBMs, revealing structural determinants and the inhibitory role of the PDZ domain on phosphatase activity.

bioRxiv · Mar 23, 2023 · PreprintBiophysics

Interactions of SARS-CoV-2 protein E with cell junctions and polarity PDZ-containing proteins

Y. Zhu, F. Alvarez, N. Wolff, A. Mechaly, S. Brule, B. Neitthoffer, s. Etienne-Manneville, A. Haouz, B. Boeda, C. Caillet-Saguy

This study investigates how SARS-CoV-2 protein E interacts with PDZ-containing proteins involved in cell junctions and polarity, showing structural and functional differences between variants.

bioRxiv · Dec 4, 2021 · PreprintBiochemistry

PDZ-containing proteins targeted by the ACE2 receptor

C. Caillet-Saguy, N. Wolff

The paper identifies 14 human PDZ-domain proteins that bind to the ACE2 PBM, revealing potential roles in ACE2 trafficking and viral entry, with implications for neurological effects of COVID-19.

bioRxiv · Jul 23, 2021Biochemistry

Host PDZ-containing proteins targeted by SARS-Cov-2

C. Caillet-Saguy, F. Durbesson, V. V. REZELJ, G. Gogl, Q. D. Tran, J.-C. Twizere, M. Vignuzzi, R. Vincentelli, N. Wolff

The paper identifies sixteen human PDZ binders of SARS-CoV-2 proteins E, 3a, and N, showing significant interactions and potential roles in viral replication and immune evasion.

bioRxiv · Feb 1, 2021Biochemistry

Interactomic affinity profiling by holdup assay: acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase

P. Jane, G. Gogl, C. Kostmann, G. Bich, V. Girault, C. Caillet-Saguy, P. Eberling, R. Vincentelli, N. Wolff, G. Trave, Y. Nomine

The paper measures PDZ domain-binding affinity of PTEN PBM using holdup assay and fluorescence polarization, showing modulatory residues and acetylation affect specificity.

bioRxiv · Jul 1, 2020Biophysics