R. Vincentelli

A gut meta-interactome map reveals modulation of human immunity by microbiome effectors

The paper identifies a gut microbiome meta-interactome map showing how bacterial effectors modulate human immunity and are enriched in Crohn's disease.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells

The paper introduces a light-inducible T cell engager system to study how temporal TCR stimulation patterns influence T cell activation and cytokine responses.

Host PDZ-containing proteins targeted by SARS-Cov-2

The paper identifies sixteen human PDZ binders of SARS-CoV-2 proteins E, 3a, and N, showing significant interactions and potential roles in viral replication and immune evasion.

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

This study isolates recombinant human septin octamers with distinct SEPT9 isoforms and shows they form filament assemblies and bind actin filaments.

Interactomic affinity profiling by holdup assay: acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase

The paper measures PDZ domain-binding affinity of PTEN PBM using holdup assay and fluorescence polarization, showing modulatory residues and acetylation affect specificity.

A gated relaxation oscillator controls morphogenetic movements in bacteria

The paper identifies a gated relaxation oscillator mechanism in Myxococcus xanthus that controls polarity reversals through FrzX and RomR, enabling tunable motility responses.