C. Carmona-Fontaine

The paper introduces an ex vivo model called 3MIC to study metastatic features in tumor cells under various metabolic conditions and stromal interactions, finding that extracellular acidification is more critical than hypoxia in promoting metastasis.

The paper shows hypoxia enhances the inflammatory fibroblast phenotype in pancreatic cancer through HIF-1 activation, promoting tumor progression.

The paper introduces the MEMIC, an ex vivo model of the tumor microenvironment, and demonstrates its ability to study nutrient effects and cell-cell interactions.

The paper develops a model to predict evolution in expanding populations by analyzing the trade-off between growth and dispersal rates.