Author

K. M. Tsanov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. W. Lowe· 3 shared C. A. Iacobuzio-Donahue· 2 shared J. Simon· 2 shared T. Baslan· 2 shared A. Chaves-Perez· 1 shared A. D. Gioacchino· 1 shared A. Karacay· 1 shared A. N. Wuest· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

S. W. Lowe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

S. Sun, J. Hong, E. You, K. M. Tsanov, J. Chacon-Barahona, A. D. Gioacchino, D. Hoyos, H. Li, H. Jiang, H. Ly, S. A. Marhon, R. Murali, P. Chanda, A. Karacay, N. Vabret, , B. D. Greenbaum

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

bioRxiv · May 19, 2023 · PreprintCancer Biology

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

S. Lowe, F. M. Barriga, K. M. Tsanov, Y. J. Ho, N. Sohail, A. Zhang, T. Baslan, A. N. Wuest, I. Del Priore, B. Meskauskaite, G. Livshits, D. Alonso-Curbelo, J. Simon, A. Chaves-Perez, D. Bar-Sagi, , D. Pe'er

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

bioRxiv · Aug 22, 2022 · PreprintCancer Biology

Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

S. Schwörer, M. Ros, K. M. Tsanov, F. V. Cimino, S. W. Lowe, C. Carmona-Fontaine, C. B. Thompson

The paper shows hypoxia enhances the inflammatory fibroblast phenotype in pancreatic cancer through HIF-1 activation, promoting tumor progression.

bioRxiv · Jul 26, 2022Cell Biology

Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease

J. Leibold, C. Amor, K. M. Tsanov, Y.-J. Ho, F. J. Sanchez-Rivera, J. Feucht, T. Baslan, H.-A. Chen, S. Tian, J. Simon, A. Wuest, J. E. Wilkinson, S. W. Lowe

This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.

bioRxiv · Jun 15, 2022Cancer Biology