C. Dehio

Full-length structure of the host targeted bacterial effector Bep1 reveals a novel structural domain conserved in FIC effector proteins from Bartonella

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.

Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella

This study identifies YopJ homologs in Bartonella as T4SS effectors, showing they evolved from an ancestral T4SS effector through acquisition of a T3SS translocation signal.

The putative Type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella

This study identifies BspD as critical for maintaining Brucella envelope integrity under stress, showing its role in bacterial survival within host cells.

BNIP3L-mediated mitophagy triggered by Brucella in host cells is required for bacterial egress

This study shows that Brucella abortus induces BNIP3L-mediated mitophagy to facilitate bacterial egress from host cells.

Antibiotic persistence of Brucella abortus in its protective intracellular niche

This study shows that Brucella abortus can form persisters under antibiotic treatment in macrophages, which may explain relapses in Brucellosis.

Bartonella taylorii: A model organism for studying Bartonella infection in vitro and in vivo

This paper introduces B. taylorii as a new model organism for studying Bartonella infection, showing improved in vitro and in vivo infectivity under specific growth conditions.

The Bartonella autotransporter CFA is a protective antigen and hypervariable target of neutralizing antibodies blocking erythrocyte infection

This study identifies the Bartonella autotransporter CFA as a protective antigen targeted by neutralizing antibodies that block erythrocyte infection.

Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane

This study identifies BepC as a Bartonella effector protein that triggers actin stress fiber formation by recruiting GEF-H1 to the plasma membrane, activating the RhoA/ROCK pathway.

Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein

The paper identifies structural mechanisms enabling a bacterial effector to selectively target Rac subfamily GTPases over closely related subfamilies.

A role for the VPS retromer in Brucella intracellular replication revealed by genome-wide siRNA screening

This study identifies the VPS retromer as a critical host factor required for Brucella to escape lysosomal degradation and establish its replicative niche through a genome-wide siRNA screen.