L. Martin

Machine learning recognises senescence in glioblastoma and discovers senescence-inducing compounds

The paper uses machine learning to identify senescent glioblastoma cells and discovers compounds that induce senescence in these cells.

Plasma proteome signature of canine acute haemorrhagic diarrhoea syndrome (AHDS)

The paper identifies plasma proteome alterations in dogs with acute haemorrhagic diarrhoea syndrome (AHDS) and finds several proteins are differentially expressed, suggesting potential biomarkers for diagnosis.

The genetic basis of dynamic non-photochemical quenching and photosystem II efficiency in fluctuating light reveals novel molecular targets for maize (Zea mays) improvement

This study identifies genetic variation affecting NPQ and PSII efficiency in maize using field-grown MAGIC population, highlighting CP24 as a key gene for photosynthetic improvement.

Systematic identification and characterization of novel genes in the regulation and biogenesis of photosynthetic machinery

The paper identifies 70 novel genes involved in photosynthesis regulation and biogenesis using genetics in Chlamydomonas reinhardtii and characterizes their functions through mutant proteomics.

BNIP3L-mediated mitophagy triggered by Brucella in host cells is required for bacterial egress

This study shows that Brucella abortus induces BNIP3L-mediated mitophagy to facilitate bacterial egress from host cells.

Intestinal norovirus binding patterns in non-secretor individuals

This study investigates HuNoV interactions in non-secretor individuals, showing that GII.4 and GII.17 VLPs bind to Lea antigen in intestinal tissues, while GII.3 shows variable binding.

Crosstalk between enterocytes and innate lymphoid cells drives early IFN-g-mediated control of Cryptosporidium

This study shows enterocytes promote ILC production of IFN-gamma, which restricts Cryptosporidium growth by acting on enterocytes themselves.

Cohesin-independent STAG proteins interact with RNA and localise to R-loops to promote complex loading.

The paper shows SA proteins interact with RNA and R-loops to promote cohesin loading independently of NIPBL, revealing a new role in chromatin structure and cancer biology.

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

This study shows that KLF10 integrates circadian timing and sugar signaling in the liver to regulate metabolism and prevent glucose intolerance and hepatic steatosis.

A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques.

This study evaluates a recombinant SARS-CoV-2 vaccine in macaques, showing that antigens from the RBD elicit high-titer neutralizing antibodies lasting over 20 weeks.

Specific norovirus interaction with Lewis x and Lewis a on human intestinal inflammatory mucosa during refractory inflammatory bowel disease

The paper investigates norovirus binding to Lewis antigens in inflammatory bowel disease tissues, showing strong interaction with sLea and sLex in CD and UC.

Full-field optical coherence tomography for the diagnosis of giant cell arteritis

This paper introduces FF-OCT for rapid, automated diagnosis of GCA by analyzing structural changes in temporal artery biopsies.

Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication

This study analyzes ancient sheep DNA from Anatolia to reveal a complex demographic history, including a domestication bottleneck and later admixture from other regions.

Disruption of AtHAK/KT/KUP9 enhances plant cesium accumulation under low potassium supply

This study shows that disrupting KUP9 in Arabidopsis thaliana increases cesium accumulation under low potassium supply and reduces cesium release.

Trans-epithelial Fluid Pumping Performance of Renal Epithelial Cells and Mechanics of Cystic Expansion

This study uses a microfluidic platform to show renal epithelial cells generate hydraulic pressure gradients, with PKD cells showing reversed fluid flow and higher stall pressure.

The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues

This study synthesizes and characterizes new psychoactive substances (NPS) and evaluates their pharmacology at cannabinoid receptors.

Clinical and MRI changes of puborectalis and iliococcygeus after a short period of intensive pelvic floor muscles training with or without instrumentation. A randomized study

This study evaluates the effects of 3 weeks of intensive pelvic floor muscle training with or without instrumentation on clinical and MRI outcomes of puborectalis and iliococcygeus muscles.

Addressing the digital divide in contemporary biology: Lessons from teaching UNIX

The paper presents a training model to teach UNIX command-line tools to biomedical researchers with little to no prior knowledge.

Humans are colonized by many uncharacterized and highly divergent microbes

The paper identifies hundreds of new bacteria and viruses in the human microbiome using blood-based shotgun sequencing and validates their existence through independent experiments and PCR.