CCR5 deficiency impairs CD4+ T cell memory responses and antigenic sensitivity through increased ceramide synthesis
A. Martin, R. Blanco, J. Casas, M. E. Saez, E. Rodriguez-Bovolenta, I. E. de Rojas, C. Drechsler, L. M. Real, G. Fabrias, A. Ruiz, M. Castro, W. W. A. Schamel, B. Alarcon, H. M. van Santen, S. Manes
This study shows that CCR5 deficiency in CD4+ T cells increases ceramide synthesis, reduces TCR nanoclustering, and impairs memory responses and antigenic sensitivity.
bioRxiv · Feb 14, 2020Immunology