A. Ruiz

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.

Accelerated Hematopoietic Stem Cell Aging in Space

This study shows spaceflight accelerates hematopoietic stem cell aging through molecular changes like reduced dormancy and mutagenesis, suggesting potential for prevention.

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

This study shows CHCHD2 promotes glioblastoma cell proliferation, hypoxia-induced invasion, and drug resistance by affecting mitochondrial function and nuclear signaling.

Trait-specific indirect effects underlie variation in the response of spiders to cannibalistic social partners

The paper investigates how genetic and environmental traits of social partners influence the behavioral response of wolf spiders to conspecific cues, finding that indirect effects drive variation in focal individuals' behavior.

Quantitative proteomic analysis of skeletal muscles from wild type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

The paper quantitatively analyzes proteomic differences in skeletal muscles of wild type and Ryr1 mutant mice, revealing reduced RyR1 and altered protein content linked to congenital myopathies.

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

This study compares short- and long-term systemic responses to SARS-CoV-2 and IAV in golden hamsters, finding persistent inflammation in olfactory tissues post-recovery.

Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors

This study treats a mouse model of congenital myopathy with HDAC and DNA methyltransferase inhibitors, improving muscle strength and RyR1 protein content.

Rapid and reproducible MALDI-TOF-based method for detection Vancomycin-resistant Enterococcus faecium using classifying algorithms

This study evaluates MALDI-TOF MS for detecting vancomycin-resistant Enterococcus faecium using classification algorithms, achieving 77.53-86.65% accuracy in distinguishing resistance types.

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancer

The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.

CCR5 deficiency impairs CD4+ T cell memory responses and antigenic sensitivity through increased ceramide synthesis

This study shows that CCR5 deficiency in CD4+ T cells increases ceramide synthesis, reduces TCR nanoclustering, and impairs memory responses and antigenic sensitivity.

Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.