Author

C. M. Waterman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Assay:imaging· 4 Organism:human· 3 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. A. Springer· 2 shared V. Jaumouille· 2 shared A. Cameron· 1 shared A. E. Goldman· 1 shared A. J. Trexler· 1 shared A. Upadhyaya· 1 shared A. V. Vahabikashi· 1 shared A. X. Cartagena-Rivera· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

T. A. Springer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Lamin B Receptor Upregulation in Metastatic Melanoma Causes Cholesterol-Mediated Nuclear Envelope Fragility

M. A. Baird, R. S. Fischer, C. E. Jewett, D. Malide, A. X. Cartagena-Rivera, C. M. Waterman

This study shows that increased LBR cholesterol synthase activity in metastatic melanoma leads to nuclear envelope fragility by accumulating cholesterol, promoting NE rupture during cell migration.

bioRxiv · Dec 21, 2023Cell Biology

Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling

M. H. Jo, J. Li, V. Jaumouille, Y. Hao, J. Coppola, J. Yan, C. M. Waterman, T. A. Springer, T. Ha

The paper investigates subtype-specific mechanics of β1 integrins in cell spreading, showing different tension thresholds and cytoskeletal remodeling for integrin α4β1 versus RGD-binding integrins.

bioRxiv · Jun 8, 2022 · PreprintBiophysics

A B cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

J. C. Wang, Y.-I. Yim, X. Wu, V. Jaumouille, A. Cameron, C. M. Waterman, J. H. Kehrl, J. A. Hammer

The paper shows that an actomyosin arc network formed by LFA-1:ICAM-1 interactions is essential for integrin-dependent immune synapse formation in B cells.

bioRxiv · Aug 12, 2021Immunology

Mechanosensing through direct binding of tensed F-actin by LIM domains

X. Sun, D. Y. Z. Phua, L. Axiotakis, M. A. Smith, E. Blankman, R. Gong, R. C. Cail, S. Espinosa de los Reyes, M. C. Beckerle, C. M. Waterman, G. M. Alushin

The paper identifies LIM domains' direct binding to tensed F-actin as a mechanosensing mechanism, showing force-dependent sequestration affects nuclear localization.

bioRxiv · Mar 6, 2020Biophysics

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope rupture

C. M. Waterman, H. R. Thiam, S. L. Wong, R. Qiu, M. Kittisopikul, A. V. Vahabikashi, A. E. Goldman, R. D. V. Goldman, D. D. Wagner

This study uses live-cell imaging to characterize the step-wise cellular events of NETosis in neutrophils and identifies PAD4's role in chromatin de-condensation and nuclear envelope rupture.

bioRxiv · Jun 6, 2019Immunology

Single-shot super-resolution total internal reflection fluorescence microscopy

M. Guo, P. Chandris, J. P. Giannini, A. J. Trexler, R. Fischer, J. Chen, H. D. Vishwasrao, I. Rey-Suarez, Y. Wu, C. M. Waterman, G. H. Patterson, A. Upadhyaya, J. Taraska, H. Shroff

This paper introduces a method combining instant structured illumination microscopy with TIRF to achieve higher resolution and faster imaging of live samples near the coverslip.

bioRxiv · Aug 29, 2017Bioengineering

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

P. Nordenfelt, T. I. Moore, S. B. Mehta, J. M. Kalappurakkal, V. Swaminathan, N. Koga, T. J. Lambert, D. Baker, J. C. Waters, R. Oldenbourg, T. Tani, S. Mayor, C. M. Waterman, T. A. Springer

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.

bioRxiv · Aug 27, 2016Cell Biology