Author

C. E. McCarthy-Leo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1 Organism:yeast· 1

Frequent Co-Authors

A. Fielder· 1 shared F. Luca· 1 shared G. Dyson· 1 shared G. S. Brush· 1 shared H. M. Gibson· 1 shared J. B. HACKETT· 1 shared J. E. Glassbrook· 1 shared J. McCasland· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Fielder

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2

C. E. McCarthy-Leo, G. S. Brush, R. Pique-Regi, F. Luca, M. A. Tainsky, R. L. Finley

The paper functionally tests most CHEK2 SNVs using a yeast complementation assay, finding 770 damaging and 2,417 tolerated variants, aiding in pathogenicity prediction.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

A Diversity Outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors

J. B. HACKETT, J. E. Glassbrook, M. C. Muniz, M. Bross, A. Fielder, G. Dyson, J. McCasland, N. Movahhedin, C. E. McCarthy-Leo, H. M. Gibson

The paper identifies prolactin as a host-intrinsic genetic regulator of response to immune checkpoint inhibitors using Diversity Outbred and Collaborative Cross mouse models.

bioRxiv · Oct 7, 2021Immunology