Author

R. Pique-Regi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Miller· 2 shared F. Luca· 2 shared J. Galaz· 2 shared R. Romero· 2 shared V. Garcia-Flores· 2 shared Y. Xu· 2 shared Z. Liu· 2 shared A. Ansari· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

D. Miller

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Author profile →

6 papers

Recent·Most cited

Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2

C. E. McCarthy-Leo, G. S. Brush, R. Pique-Regi, F. Luca, M. A. Tainsky, R. L. Finley

The paper functionally tests most CHEK2 SNVs using a yeast complementation assay, finding 770 damaging and 2,417 tolerated variants, aiding in pathogenicity prediction.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

Homeostatic macrophages prevent preterm birth and improve neonatal outcomes by mitigating in utero sterile inflammation

V. Garcia-Flores, Z. Liu, R. Romero, R. Pique-Regi, Y. Xu, D. Miller, D. Levenson, J. Galaz, A. D. Winters, M. Farias-Jofre, J. J. Panzer, K. R. Theis, N. Gomez-Lopez

The paper shows that M2 macrophages prevent preterm birth and improve neonatal outcomes by reducing in utero sterile inflammation in mice.

bioRxiv · Jul 19, 2023 · PreprintImmunology

Deconstructing cold-induced brown adipocyte neogenesis in mice

R. B. Burl, E. A. Rondini, H. Wei, R. Pique-Regi, J. G. Granneman

The paper identifies ASC1 as direct precursors of brown adipocytes and shows that immune cell recruitment and b3-adrenergic receptor activation drive cold-induced neogenesis in mice.

bioRxiv · May 23, 2022Cell Biology

The single-cell atlas of the murine reproductive tissues during preterm labor

V. Garcia-Flores, R. Romero, A. Peyvandipour, J. Galaz, E. Pusod, B. Panaitescu, D. Miller, Y. Xu, L. Tao, Z. Liu, A. L. Tarca, R. Pique-Regi, N. Nardhy Gomez-Lopez

This study uses scRNA-seq to create a single-cell atlas of murine reproductive tissues during infection-induced preterm labor, identifying gene expression signatures and intercellular communication changes.

bioRxiv · Apr 27, 2022Immunology

A termination-independent role of Rat1 in cotranscriptional splicing

Z. Dhoondia, H. Elewa, M. Malik, Z. Arif, R. Pique-Regi, A. Ansari

This study identifies a novel role of Rat1 in cotranscriptional splicing in yeast, showing it interacts with splicing factors and affects intron processing.

Nucleic Acids Research · May 12, 2021Peer-reviewedBiochemistry

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

A. Findley, X. Zhang, C. Boye, Y.-L. Lin, C. Kalita, L. Barreiro, K. E. Lohmueller, R. Pique-Regi, F. Luca

The paper identifies Neanderthal introgression variants that influence gene expression in response to environmental perturbations and validates their regulatory function.

bioRxiv · Mar 15, 2021Evolutionary Biology