A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases
A. A. Adhikari, D. Ramachandran, S. N. Chaudhari, C. E. Powell, M. D. McCurry, A. S. Banks, A. S. Devlin
The paper develops a gut-restricted BSH inhibitor, AAA-10, which effectively reduces secondary bile acids in mice with minimal systemic exposure.
bioRxiv · Mar 15, 2021Biochemistry