Author

M. D. McCurry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. S. Devlin· 3 shared A. A. Adhikari· 2 shared A. S. Banks· 2 shared D. Ramachandran· 2 shared L. Yao· 2 shared S. N. Chaudhari· 2 shared C. E. Powell· 1 shared C. Huttenhower· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

A. S. Devlin

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Author profile →

3 papers

Recent·Most cited

A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases

A. A. Adhikari, D. Ramachandran, S. N. Chaudhari, C. E. Powell, M. D. McCurry, A. S. Banks, A. S. Devlin

The paper develops a gut-restricted BSH inhibitor, AAA-10, which effectively reduces secondary bile acids in mice with minimal systemic exposure.

bioRxiv · Mar 15, 2021Biochemistry

A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

W. Li, S. Hang, Y. Fang, S. Bae, Y. Zhang, G. Wang, M. D. McCurry, M. Bae, E. A. Franzosa, C. Huttenhower, L. Yao, A. S. Devlin, J. R. Huh

This study identifies a bacterial bile acid metabolite, isoalloLCA, that enhances Treg cell differentiation via NR4A1 and is reduced in inflammatory bowel disease patients.

bioRxiv · Jan 8, 2021Immunology

Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases

A. A. Adhikari, T. C. Seegar, S. B. Ficarro, M. D. McCurry, D. Ramachandran, L. Yao, S. N. Chaudhari, S. Ndousse-Fetter, A. S. Banks, J. A. Marto, S. C. Blacklow, A. S. Devlin

This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.

bioRxiv · May 17, 2019Microbiology