Author

A. A. Sarshad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

M. E. Peter· 3 shared M. Hafner· 3 shared Q. Q. Gao· 3 shared A. E. Murmann· 2 shared A. Haluck-Kangas· 2 shared C. Fernandez· 2 shared D. Angeletti· 2 shared E. T. Bartom· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

M. E. Peter

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nuclear RNAi Modulates Influenza A Virus Infectivity By Downregulating Type-I Interferon Response

H.-C. Huang, I. Nowak, V. Lobo, D. F. Besavilla, K. Schon, J. O. Westholm, C. Fernandez, A. A. Patel, C. Wiel, V. I. Sayin, D. G. Anastasakis, D. Angeletti, A. A. Sarshad

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.

bioRxiv · Mar 7, 2024 · PreprintBiochemistry

Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference

V. Lobo, I. Nowak, C. Fernandez, A. I. Correa Muler, J. O. Westholm, H.-C. Huang, I. Fabrik, H. T. Huynh, E. Shcherbinina, M. Poyraz, A. Hartlova, D. Benhalevy, D. Angeletti, A. A. Sarshad

This study shows that loss of Lamin A causes AGO2 to move into the nucleus, impairing RNAi and increasing oncogenic miRNA expression in cancer cells.

bioRxiv · Jun 5, 2023Biochemistry

CD95/Fas ligand mRNA is toxic to cells

W. Putzbach, A. Haluck-Kangas, Q. Q. Gao, A. A. Sarshad, E. T. Bartom, A. M. Stults, A. S. Qadir, M. Hafner, M. E. Peter

The paper shows that full-length CD95L mRNA is toxic to cells and induces apoptosis through sRNA processing independent of Dicer and Drosha, suggesting a new role for RNAi in cell fate regulation.

bioRxiv · Sep 14, 2018Cancer Biology

6mer seed toxicity in tumor suppressive microRNAs

Q. Q. Gao, W. E. Putzbach, A. E. Murmann, S. Chen, A. A. Sarshad, J. M. Peter, E. T. Bartom, M. Hafner, M. E. Peter

The paper identifies 6mer seed sequences in miRNAs that are toxic to cancer cells, showing that tumor suppressive miRNAs use these toxic seeds to kill cancer cells.

bioRxiv · Aug 31, 2018Cell Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology