Author

C. Frieden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Baban· 2 shared M. D. Stuchell-Brereton· 2 shared A. Soranno· 1 shared C. E. Kluender· 1 shared D. F. Steinberg· 1 shared D. L. Kober· 1 shared D. M. Holtzman· 1 shared D. Roy· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

B. Baban

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2 papers

Recent·Most cited

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

M. D. Stuchell-Brereton, M. I. Zimmerman, J. J. Miller, U. L. Mallimadugula, J. J. Incicco, D. Roy, L. G. Smith, B. Baban, G. T. DeKoster, C. Frieden, G. R. Bowman, A. Soranno

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

bioRxiv · Feb 2, 2022Biophysics

Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42

D. L. Kober, M. D. Stuchell-Brereton, C. E. Kluender, H. B. Dean, M. R. Strickland, D. F. Steinberg, S. S. Nelson, B. Baban, D. M. Holtzman, C. Frieden, J. M. Alexander-Brett, E. D. Roberson, Y. Song, T. J. Brett

This study investigates TREM2 interactions with ApoE and Aβ1-42 using biophysical methods, revealing distinct binding surfaces and a potential role for sTREM2 in inhibiting Aβ polymerization.

Alzheimer's & Dementia · Oct 8, 2020Peer-reviewedBiophysics