J. J. Miller

A nepenthesin insert allosterically controls catalysis in the malaria parasite protease plasmepsin V

The paper identifies a nepenthesin insert essential for plasmepsin V function in malaria parasites and shows it allosterically regulates catalysis.

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria parasites

This study characterizes HAD5, a phosphomannomutase essential for GPI anchor biosynthesis in malaria parasites, showing its role in parasite egress and reinvasion and identifying a specific inhibitor.

Antimicrobial prodrug activation by the staphylococcal glyoxalase GloB

This study identifies GloB as a bacterial enzyme that activates carboxy ester prodrugs, suggesting its potential for developing targeted prodrug therapies against staphylococcal species.

Potent, specific MEPicides for treatment of zoonotic staphylococci

This paper identifies DXR as a druggable target for zoonotic staphylococci and develops potent prodrug inhibitors (MEPicides) that bypass transporter requirements.

Altered structural hub connectivity and its clinical relevance in glioma

This study examines structural hub connectivity in glioma patients and finds altered connectivity in the hemisphere opposite the tumor, linked to performance status and molecular subtypes.