Author

J. J. Incicco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Soranno· 4 shared A. S. Holehouse· 3 shared M. D. Stuchell-Brereton· 3 shared G. R. Bowman· 2 shared J. Cubuk· 2 shared J. J. Alston· 2 shared K. B. Hall· 2 shared M. I. Zimmerman· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

A. Soranno

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4 papers

Recent·Most cited

The disordered N-terminal tail of SARS CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, A. S. Holehouse, K. B. Hall, M. D. Stuchell-Brereton, A. Soranno

This study investigates how the disordered N-terminal tail of the SARS-CoV-2 Nucleocapsid protein enhances RNA binding affinity and modulates interactions with RNA.

bioRxiv · Feb 10, 2023Biophysics

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

M. D. Stuchell-Brereton, M. I. Zimmerman, J. J. Miller, U. L. Mallimadugula, J. J. Incicco, D. Roy, L. G. Smith, B. Baban, G. T. DeKoster, C. Frieden, G. R. Bowman, A. Soranno

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

bioRxiv · Feb 2, 2022Biophysics

Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA

A. Soranno, J. J. Incicco, P. De Bona, E. J. Tomko, E. Galburt, A. S. Holehouse, R. Galletto

The paper shows TRF2 drives single telomere condensation and multi-telomere phase separation, with hRap1 modulating these processes.

bioRxiv · Apr 30, 2021Biophysics

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, S. Singh, M. D. Stuchell-Brereton, M. D. Ward, M. I. Zimmerman, N. Vithani, D. Griffith, J. A. Wagoner, G. R. Bowman, K. B. Hall, A. Soranno, A. S. Holehouse

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.

bioRxiv · Jun 17, 2020Biophysics