Author

M. D. Stuchell-Brereton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Organism:virus· 2

Frequent Co-Authors

A. Soranno· 4 shared J. J. Incicco· 3 shared A. S. Holehouse· 2 shared B. Baban· 2 shared C. Frieden· 2 shared G. R. Bowman· 2 shared J. Cubuk· 2 shared J. J. Alston· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiophysics

A. Soranno

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein

O. L. Mooren, M. D. Stuchell-Brereton, P. McConnell, C. Yan, E. M. Wilkerson, D. Goldfarb, J. A. Cooper, D. Sept, A. Soranno

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

bioRxiv · Aug 16, 2023Biochemistry

The disordered N-terminal tail of SARS CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, A. S. Holehouse, K. B. Hall, M. D. Stuchell-Brereton, A. Soranno

This study investigates how the disordered N-terminal tail of the SARS-CoV-2 Nucleocapsid protein enhances RNA binding affinity and modulates interactions with RNA.

bioRxiv · Feb 10, 2023Biophysics

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

M. D. Stuchell-Brereton, M. I. Zimmerman, J. J. Miller, U. L. Mallimadugula, J. J. Incicco, D. Roy, L. G. Smith, B. Baban, G. T. DeKoster, C. Frieden, G. R. Bowman, A. Soranno

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

bioRxiv · Feb 2, 2022Biophysics

Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42

D. L. Kober, M. D. Stuchell-Brereton, C. E. Kluender, H. B. Dean, M. R. Strickland, D. F. Steinberg, S. S. Nelson, B. Baban, D. M. Holtzman, C. Frieden, J. M. Alexander-Brett, E. D. Roberson, Y. Song, T. J. Brett

This study investigates TREM2 interactions with ApoE and Aβ1-42 using biophysical methods, revealing distinct binding surfaces and a potential role for sTREM2 in inhibiting Aβ polymerization.

Alzheimer's & Dementia · Oct 8, 2020Peer-reviewedBiophysics

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, S. Singh, M. D. Stuchell-Brereton, M. D. Ward, M. I. Zimmerman, N. Vithani, D. Griffith, J. A. Wagoner, G. R. Bowman, K. B. Hall, A. Soranno, A. S. Holehouse

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.

bioRxiv · Jun 17, 2020Biophysics