A. Soranno

Accounting for fast vs slow exchange in single molecule FRET experiments reveals hidden conformational states

This study improves agreement between smFRET experiments and molecular dynamics simulations by accounting for time-averaging, revealing hidden conformational states in proteins.

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation

The paper investigates how sequence variation in intrinsically disordered regions (IDRs) can still encode functional specificity in RNA binding, using coronavirus nucleocapsid proteins as a model.

The analytical Flory random coil is a simple-to-use reference model for unfolded and disordered proteins

The paper introduces the analytical Flory Random Coil (AFRC) model as a reference for unfolded proteins, enabling comparison of experimental and simulation data.

The disordered N-terminal tail of SARS CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

This study investigates how the disordered N-terminal tail of the SARS-CoV-2 Nucleocapsid protein enhances RNA binding affinity and modulates interactions with RNA.

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

This study uses single-molecule spectroscopy and molecular dynamics simulations to show that ApoE4 has extensive conformational heterogeneity in both lipid-free and lipid-bound states, differing from previous models.

Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA

The paper shows TRF2 drives single telomere condensation and multi-telomere phase separation, with hRap1 modulating these processes.

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.