Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus
C. M. Rive, E. Yung, L. Dreolini, S. D. Brown, C. G. May, D. J. Woodsworth, R. A. Holt
This study shows that IV infusion of anti-CD19 CAR lentiviral vectors leads to persistent CAR-T cell expansion and complete B cell depletion in mice.
bioRxiv · May 15, 2020Immunology