Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations
C. M. Rive, E. Yung, C. S. Hughes, S. D. Brown, G. Sharma, L. Dreolini, N. M. Mawji, C. Warren, J. Karasinska, J. M. Loree, D. T. Yapp, G. B. Morin, D. J. Renouf, D. F. Schaeffer, S. Turcotte, R. A. Holt
The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.
bioRxiv · Jun 15, 2020 · PreprintImmunology