Author

R. A. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Animal Behavior & Cognition· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:Drosophila· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. D. Brown· 3 shared C. M. Rive· 2 shared E. Yung· 2 shared K. J. Weaver· 2 shared L. Dreolini· 2 shared A. V. Robinson· 1 shared C. G. May· 1 shared C. S. Hughes· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

S. D. Brown

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Behavioral dissection of hunger states in Drosophila

K. J. Weaver, S. Raju, R. A. Rucker, T. Chakraborty, R. A. Holt, S. Pletcher

The paper distinguishes hedonic and homeostatic hunger states in Drosophila by analyzing behaviors and neuronal activity, identifying the PAM to β MB circuit as involved in hedonic feeding motivation.

bioRxiv · Nov 11, 2022 · PreprintAnimal Behavior & Cognition

Encoding of hunger by the neuronal epigenome slows aging in Drosophila

K. J. Weaver, R. A. Holt, E. Henry, S. D. Pletcher

This study shows that encoding hunger through neuronal epigenome changes slows aging in Drosophila by altering histone acetylation and BCAA metabolism.

bioRxiv · Jul 21, 2022 · PreprintPhysiology

Invasion by Fusobacterium nucleatum Causes Upregulation of dll4 and klf4 Expression in Caco-2 Cells

E. Allen-Vercoe, K. Cochrane, A. V. Robinson, J. Powers, S. D. Brown, R. A. Holt

The paper investigates how invasive Fusobacterium nucleatum strains upregulate host genes dll4 and klf4 in Caco-2 cells compared to a non-invasive E. coli control.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

C. M. Rive, E. Yung, C. S. Hughes, S. D. Brown, G. Sharma, L. Dreolini, N. M. Mawji, C. Warren, J. Karasinska, J. M. Loree, D. T. Yapp, G. B. Morin, D. J. Renouf, D. F. Schaeffer, S. Turcotte, R. A. Holt

The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.

bioRxiv · Jun 15, 2020 · PreprintImmunology

Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus

C. M. Rive, E. Yung, L. Dreolini, S. D. Brown, C. G. May, D. J. Woodsworth, R. A. Holt

This study shows that IV infusion of anti-CD19 CAR lentiviral vectors leads to persistent CAR-T cell expansion and complete B cell depletion in mice.

bioRxiv · May 15, 2020Immunology