Author

C. Paulino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 5 Approach:experimental assay· 5 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. A. Garaeva· 2 shared D. J. Slotboom· 2 shared G. T. Oostergetel· 2 shared J. Rheinberger· 2 shared R. Dutzler· 2 shared V. Clerico Mosina· 2 shared A. Schlessinger· 1 shared C. A. J. Hutter· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. A. Garaeva

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Author profile →

6 papers

Recent·Most cited

Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC

J. M. Silberberg, R. A. Corey, L. Hielkema, C. Stock, P. J. Stansfeld, C. Paulino, I. Haenelt

The paper investigates ion transport and ATPase coupling in KdpFABC using cryo-EM, biochemical assays, and MD simulations, revealing conserved mechanisms across P-type ATPases.

bioRxiv · May 18, 2021Biophysics

Optimized cryo-EM data acquisition workflow by sample thickness determination

J. Rheinberger, G. Oostergetel, G. P. Resch, C. Paulino

This paper optimizes cryo-EM data acquisition by determining sample thickness before collection, improving efficiency and reducing suboptimal image capture.

bioRxiv · Dec 1, 2020 · PreprintBiophysics

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

J. D. Walter, C. A. J. Hutter, A. A. Garaeva, M. Scherer, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J. C. Earp, P. Egloff, M. Sorgenfrei, L. Hürlimann, I. Gonda, G. Meier, S. Remm, , M. A. Seeger

bioRxiv · Nov 10, 2020Biochemistry

Structural basis for stereospecific inhibition of ASCT2 from rational design

R.-A. A. Garibsingh, E. Ndaru, A. A. Garaeva, M. Bonomi, D. J. Slotboom, C. Paulino, C. Grewer, A. Schlessinger

The paper rationally designs inhibitors for ASCT2 using computational modeling and cryo-EM, showing how stereospecific pockets can be exploited for drug discovery.

bioRxiv · May 29, 2020Biochemistry

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

V. Kalienkova, V. Clerico Mosina, L. Bryner, G. T. Oostergetel, R. Dutzler, C. Paulino

This study uses cryo-EM to reveal the stepwise activation mechanism of nhTMEM16, showing how Ca2+-binding induces conformational changes that facilitate lipid scrambling.

bioRxiv · Feb 5, 2019Biochemistry

Cryo-EM structures and functional characterization of the lipid scramblase TMEM16F

C. Alvadia, N. K. Lim, V. Clerico Mosina, G. T. Oostergetel, R. Dutzler, C. Paulino

This study presents cryo-EM structures of TMEM16F in different states and shows how its function as a lipid scramblase and ion channel relates to conformational changes.

bioRxiv · Oct 29, 2018Biochemistry