The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
P. M. Exconde, C. Hernandez-Chavez, M. B. Bray, J. L. Lopez, T. Srivastava, M. S. Egan, J. Zhang, S. Shin, B. M. Discher, C. Y. Taabazuing
This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.
bioRxiv · Feb 16, 2023 · PreprintImmunology