Author

M. S. Egan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Shin· 2 shared A. R. Bass· 1 shared B. M. Discher· 1 shared B. Zuo· 1 shared C. Hernandez-Chavez· 1 shared C. Y. Taabazuing· 1 shared E. A. O'Rourke· 1 shared E. N. Hunter· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

S. Shin

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

M. S. Egan, E. A. O'Rourke, S. K. Mageswaran, B. Zuo, I. Martynyuk, T. Demissie, E. N. Hunter, A. R. Bass, Y.-W. Chang, I. E. Brodsky, S. Shin

This study identifies caspase-1 and GSDMD as key mediators of inflammasome responses that restrict Salmonella replication in human macrophages.

bioRxiv · Jul 17, 2023Microbiology

The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases

P. M. Exconde, C. Hernandez-Chavez, M. B. Bray, J. L. Lopez, T. Srivastava, M. S. Egan, J. Zhang, S. Shin, B. M. Discher, C. Y. Taabazuing

This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.

bioRxiv · Feb 16, 2023 · PreprintImmunology