Author

C. Hierro-Yap

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Zikova· 3 shared A. Hemphill· 1 shared B. Panicucci· 1 shared D. Arbon· 1 shared D. Schädeli· 1 shared E. Pineda· 1 shared F. Bringaud· 1 shared F. Zahedifard· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

A. Zikova

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Trypanosoma brucei bloodstream form mitochondrion is capable of ATP production by substrate phoshorylation

G. Taleva, M. Husova, B. Panicucci, C. Hierro-Yap, E. Pineda, M. Biran, M. Moos, P. Simek, F. Bringaud, A. Zikova

This study shows that Trypanosoma brucei mitochondria can produce ATP via substrate phosphorylation, which is crucial under nutrient-limited conditions.

bioRxiv · May 26, 2023 · PreprintMicrobiology

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

D. Arbon, K. Zeniskova, K. Subrtova, J. Mach, J. Stursa, M. Machado, F. Zahedifard, T. Lestinova, C. Hierro-Yap, J. Neuzil, P. Volf, M. Ganter, M. Zoltner, A. Zikova, L. Werner, R. Sutak

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms

M. Serricchio, C. Hierro-Yap, D. Schädeli, H. Ben Hamidane, A. Hemphill, J. Graumann, A. Zikova, P. Bütikofer

This study shows that depletion of cardiolipin in Trypanosoma brucei bloodstream forms disrupts mitochondrial function and energy metabolism, leading to reduced ATP levels and altered metabolic pathways.

bioRxiv · Jun 15, 2020Biochemistry