Author

T. Lestinova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P. Volf· 4 shared J. Sadlova· 2 shared A. Freitas-Mesquita· 1 shared A. Guimaraes-Costa· 1 shared A. Zikova· 1 shared C. Enes· 1 shared C. Hierro-Yap· 1 shared D. Arbon· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMicrobiology

P. Volf

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion

M. Florencio, M. Chagas, A. Guimaraes-Costa, J. Oliveira, I. Waclawiak, T. Oliveira, E. M. Saraiva, A. Freitas-Mesquita, J. R. Meyer-Fernandes, L. Aragao-Farias, C. Enes, P. Cuervo, R. Nascimento, O. C. Moreira, F. Ribeiro-Gomes, , M. C. Boite

This study examines how a sub-chromosomal deletion in Leishmania infantum affects parasite virulence, transmission, and drug resistance, suggesting it may enhance geographic spread.

bioRxiv · May 22, 2024 · PreprintMicrobiology

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

D. Arbon, K. Zeniskova, K. Subrtova, J. Mach, J. Stursa, M. Machado, F. Zahedifard, T. Lestinova, C. Hierro-Yap, J. Neuzil, P. Volf, M. Ganter, M. Zoltner, A. Zikova, L. Werner, R. Sutak

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific

M. A. Sloan, J. Sadlova, T. Lestinova, M. Sanders, J. A. Cotton, P. Volf, P. Ligoxygakis

The paper examines the transcriptomic response of sand flies to trypanosomatid-contaminated blood, finding a generalized response to blood meals rather than specific parasite-related changes.

bioRxiv · Dec 6, 2019 · PreprintImmunology

Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

T. Beneke, F. Demay, E. Hookway, N. Ashman, H. Jeffery, J. Smith, J. Valli, T. Becvar, J. Myskova, T. Lestinova, S. Shafiq, J. Sadlova, P. Volf, R. J. Wheeler, E. Gluenz

This study identifies flagellar proteins in Leishmania and shows that directional motility is essential for parasite colonization of sand flies.

bioRxiv · Nov 27, 2018Cell Biology